解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Colorectal cancer is third most common malignancy and is the second most common cause of cancer-related death. The MUC1 heterodimeric protein is aberrantly overexpressed in colorectal cancer and has been linked to poor outcomes in this disease. Here, we investigate the effects of the MUC1-C subunit inhibitor...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-017-0608-9
更新日期:2017-02-02 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) and cancer stem-like cells (CSC) are becoming highly relevant targets in anticancer drug discovery. A large body of evidence suggests that epithelial-mesenchymal transitioned tumor cells (EMT tumor cells) and CSCs have similar functions. There is also an overlap regarding the st...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-016-0573-8
更新日期:2017-01-30 00:00:00
abstract:BACKGROUND:Taurine upregulated gene1 (TUG1) as a 7.1-kb lncRNA, has been shown to play an oncogenic role in various cancers. However, the biological functions of lncRNA TUG1 in small cell lung cancer (SCLC) remain unknown. The aim of this study is to explore the roles of TUG1 in cell growth and chemoresistance of SCLC ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-016-0575-6
更新日期:2017-01-09 00:00:00
abstract::Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established cell lines. Therefore, the proper use of in vitro models is crucial to enhance our understanding of cancer. Ther...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-016-0565-8
更新日期:2016-12-19 00:00:00
abstract:BACKGROUND:Glioblastomas (GBM) continue to remain one of the most dreaded tumours that are highly infiltrative in nature and easily preclude comprehensive surgical resection. GBMs pose an intricate etiology as they are being associated with a plethora of genetic and epigenetic lesions. Misregulation of the PI3 kinase p...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-016-0557-8
更新日期:2016-11-21 00:00:00
abstract::MicroRNAs (miRNAs) are emerging as central players in shaping the biology of the Tumor Microenvironment (TME). They do so both by modulating their expression levels within the different cells of the TME and by being shuttled among different cell populations within exosomes and other extracellular vesicles. This review...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-016-0525-3
更新日期:2016-05-26 00:00:00
abstract::Prostate cancer, the second most frequently diagnosed cancer in males worldwide, is estimated to be diagnosed in 1.1 million men per year. Introduction of PSA testing substantially improved early detection of prostate cancer, however it also led to overdiagnosis and subsequent overtreatment of patients with an indolen...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-016-0523-5
更新日期:2016-05-18 00:00:00
abstract:BACKGROUND:Sorafenib, a kinase inhibitor active against various solid tumours, induces oxidative stress and ferroptosis, a new form of oxidative necrosis, in some cancer cells. Clinically-applicable biomarkers that reflect the impact of sorafenib on the redox metabolism of cancer cells are lacking. METHODS:We used gen...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-016-0526-2
更新日期:2016-05-16 00:00:00
abstract:BACKGROUND:Epigenetic regulators play a critical role in the maintenance of specific chromatin domains in an active or repressed state. Disruption of epigenetic regulatory mechanisms is widespread in cancer cells and largely contributes to the transformation process through active repression of tumor suppressor genes. ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-016-0500-z
更新日期:2016-02-16 00:00:00
abstract:BACKGROUND:Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target of rapamycin (mTOR) pathway is associated with various pancreatic neoplasms. We thus aimed at analyz...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0483-1
更新日期:2015-12-18 00:00:00
abstract:BACKGROUND:High expression of the long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) in whole blood has been reported in colorectal cancer patients; however, its' clinical significance and origin are unclear. We evaluated the diagnostic and prognostic value, and origin of whole blood NEAT1 in colorectal...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0455-5
更新日期:2015-11-09 00:00:00
abstract:BACKGROUND:The tumor cell lysate-pulsed, dendritic cell (DC)-based cancer vaccine approaches are being actively evaluated for application to cancer immunotherapy, hopefully at a personalized medicine base. There is apparently an emerging technical problem however, the lack of highly efficacious potency in activation of...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0435-9
更新日期:2015-09-24 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and the biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including HCC. Taurine Up-regulated Gene...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0431-0
更新日期:2015-09-04 00:00:00
abstract:BACKGROUND:Previous studies have established that levels of the Inhibitor of Growth 1(ING1) tumor suppressor are reduced in a significant proportion of different cancer types. Here we analyzed levels of ING1 in breast cancer patients to determine its prognostic significance as a biomarker for breast cancer prognosis. ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0434-x
更新日期:2015-08-27 00:00:00
abstract:BACKGROUND:Most ovarian cancers are highly invasive in nature and the high burden of metastatic disease make them a leading cause of mortality among all gynaecological malignancies. The homeodomain transcription factor, PITX2 is associated with cancer in different tissues. Our previous studies demonstrated increased PI...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0433-y
更新日期:2015-08-23 00:00:00
abstract:BACKGROUND:The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a common form of pediatric brain cancer. While the fundamentals of this pathway are known, the molecular...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0430-1
更新日期:2015-08-19 00:00:00
abstract:BACKGROUND:The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in the mouse and that human metastatic melanomas had reduced AhR levels with respect to benig...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0419-9
更新日期:2015-08-05 00:00:00
abstract:BACKGROUND:Hypoxia can halt cell cycle progression of several cell types at the G1/S interface. The arrest needs to be overcome by cancer cells. We have previously shown that the hypoxia-inducible cellular oxygen sensor PHD3/EGLN3 enhances hypoxic cell cycle entry at the G1/S boundary. METHODS:We used PHD3 knockdown b...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0410-5
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:An increased incidence of venous thromboembolism (VTE) is associated with anti-vascular endothelial growth factor (VEGF) treatment in cancer. However, the mechanism underlying this effect remains elusive. In this study, we examined the effect of bevacizumab, a humanized monoclonal antibody against VEGF-A, on...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0418-x
更新日期:2015-07-29 00:00:00
abstract:BACKGROUND:Salivary Adenoid cystic carcinoma (SACC) patients with local invasion and lung metastasis are often resistant to conventional therapy such as operation, chemotherapy and radiotherapy. To explore the underling mechanisms, we studied the roles of miRNA in regulating invasiveness of SACC cells. METHODS:MicroRN...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0344-y
更新日期:2015-04-29 00:00:00
abstract::Infection with Human papillomaviruses (HPVs) leads to the development of a wide-range of cancers, accounting for 5% of all human cancers. A prominent example is cervical cancer, one of the leading causes of cancer death in women worldwide. It has been well established that tumor development and progression induced by ...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-015-0361-x
更新日期:2015-04-17 00:00:00
abstract:BACKGROUND:Among women worldwide, breast cancer is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths. Improved understanding of breast tumourigenesis may facilitate the development of more effective therapies. Peroxisome proliferator-activated receptor (PPAR)γ is a transcription ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0347-8
更新日期:2015-04-15 00:00:00
abstract:BACKGROUND:Hedgehog acyltransferase (Hhat) catalyzes the transfer of the fatty acid palmitate onto Sonic Hedgehog (Shh), a modification that is essential for Shh signaling activity. The Shh signaling pathway has been implicated in the progression of breast cancer. METHODS:To determine the functional significance of Hh...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0345-x
更新日期:2015-04-01 00:00:00
abstract::IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evid...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-015-0291-7
更新日期:2015-02-15 00:00:00
abstract:BACKGROUND:Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most de...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-015-0288-2
更新日期:2015-02-03 00:00:00
abstract:BACKGROUND:The epithelial-to-mesenchymal transition (EMT) process results in a loss of cell-cell adhesion, increased cell mobility, and is crucial for enabling the metastasis of cancer cells. Recently, the enzyme SIRT1 has been implicated in a variety of physiological processes; however, its role in regulating oral can...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-254
更新日期:2014-11-26 00:00:00
abstract:BACKGROUND:For long, natural killer (NK) cells have been suspected to play a critical role in suppressing the development of spontaneous metastases in cancer patients. Despite a wide range of studies it remains unclear so far to what extent primary tumor growth together with formation of distant metastases and NK cell ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-244
更新日期:2014-11-05 00:00:00
abstract:BACKGROUND:The AKT/mammalian target of rapamycin (mTOR) signaling pathway is regulated by 17α-estradiol (E2) signaling and mediates E2-induced proliferation and progesterone receptor (PgR) expression in breast cancer. METHODS AND RESULTS:Here we use deep sequencing analysis of previously published data from The Cancer...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-229
更新日期:2014-10-06 00:00:00
abstract:INTRODUCTION:ERBB3, one of the four members of the ErbB family of receptor tyrosine kinases, plays an important role in breast cancer etiology and progression. In the present study, we aimed to identify novel miRNAs that can potentially target ERBB3 and their biological functions. METHOD:The expression levels of miR-1...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-220
更新日期:2014-09-24 00:00:00
abstract:INTRODUCTION:Tumor-initiating cells (TICs), aka "cancer stem cells", are believed to fuel tumors and to sustain therapy resistance and systemic metastasis. Breast cancer is the first human carcinoma in which a subpopulation of cells displaying a specific CD44+/CD24-/low/ESA+ antigenic phenotype was found to have TIC pr...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-213
更新日期:2014-09-12 00:00:00
abstract:BACKGROUND:Recent advances have revealed a significant contribution of chemokines and their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis. The CXC chemokine receptor-7 (CXCR7) is the latest chemokine receptor implicated in cancer. Although over expressed in breast cancer cell lin...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-198
更新日期:2014-08-28 00:00:00
abstract:BACKGROUND:Ambiguity in malignant transformation of glioma has made prognostic diagnosis very challenging. Tumor malignant transformation is closely correlated with specific alterations of the metabolic profile. Exploration of the underlying metabolic alterations in glioma cells of different malignant degree is therefo...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-197
更新日期:2014-08-27 00:00:00
abstract:BACKGROUND:Darpp-32 and t-Darpp are expressed in several forms of breast cancer. Both are transcribed from the gene PPP1R1B via alternative promoters. In humans, Darpp-32 is expressed in both normal and malignant breast tissue, whereas t-Darpp has only been found in malignant breast tissue. The exact biological functio...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-192
更新日期:2014-08-15 00:00:00
abstract:BACKGROUND:Insulin enhancer binding protein-1 (ISL-1), a LIM-homeodomain transcription factor, is essential for the heart, motor neuron and pancreas development. Recently, ISL-1 has been found in some types of human cancers. However, how ISL-1 exerts the role in tumor development is not clear. METHODS AND RESULTS:The ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-181
更新日期:2014-07-29 00:00:00
abstract:BACKGROUND:Lung cancer in nonsmokers tends to be driven by a single somatic mutation or a gene fusion. KIF5B-RET fusion is an oncogene identified in non-small cell lung cancers. In this study, we verified the oncogenic activity of KIF5B-RET fusion and investigated how KIF5B-RET activates the specific signaling pathways...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-176
更新日期:2014-07-21 00:00:00
abstract:BACKGROUND:microRNAs (miRNAs) play both oncogenic and oncostatic roles in leukemia. However, the molecular details underlying miRNA-mediated regulation of their target genes in pediatric B- and T-cell acute lymphoblastic leukemias (ALLs) remain unclear. The present study investigated the relationship between miR-2909 a...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-175
更新日期:2014-07-18 00:00:00
abstract:BACKGROUND:The influence of natural regulatory T cells (nTregs) on the patients with colon cancer is unclear. Demethylated status of the Treg-specific demethylated region (TSDR) of the FOXP3 gene was reported to be a potential biomarker for the identification of nTregs. METHODS:The demethylation rate of the TSDR (TSDR...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-153
更新日期:2014-06-18 00:00:00
abstract:BACKGROUND:Targeted therapies have improved therapeutic options of treating renal cell carcinoma (RCC). However, drug response is temporary due to resistance development. METHODS:Functional and molecular changes in RCC Caki-1 cells, after acquired resistance to the mammalian target of rapamycin (mTOR)-inhibitor everol...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-152
更新日期:2014-06-16 00:00:00
abstract:BACKGROUND:MicroRNA-10b (miR-10b) has a prominent role in regulating tumor invasion and metastasis by targeting the HOXD10 transcriptional repressor and has been found up-regulated in several tumor types. METHODS:We evaluated the expression of miR-10b in paired tumor and normal specimens obtained from a prospective co...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-142
更新日期:2014-06-04 00:00:00
abstract:BACKGROUND:The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to cancer malignancy remains unclear. Previously, we reported that ribophorin II (RPN2), which is part of an N-oligosaccharyle transferase complex, is respon...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/1476-4598-13-134
更新日期:2014-05-31 00:00:00